Application of Aigtek Power Amplifier in Magnetic Particle Classification and Magnetic Detection Test
“The detection limit and precision are affected. Direct detection of the antigen-antibody reaction through the magnetic properties of magnetic particles can eliminate these unfavorable factors and improve the sensitivity and accuracy of the detection method. Magnetic signal detection can also be used in conjunction with optical detection methods to improve the accuracy and reliability of automatic analysis.
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Experiment name：The application of power amplifier in magnetic particle classification and magnetic detection test
Purpose: Due to the obvious absorption and scattering effects of magnetic particles on light, MEIA technology based on optical detection methods
The detection limit and precision are affected. Direct detection of the antigen-antibody reaction through the magnetic properties of magnetic particles can eliminate these unfavorable factors and improve the sensitivity and accuracy of the detection method. Magnetic signal detection can also be used in conjunction with optical detection methods to improve the accuracy and reliability of automatic analysis.
Laboratory equipment: Signal generator, power amplifier ATA-4012, oscilloscope, digital multimeter, high-precision stabilized power supply, drive core, coil, etc.
Carry out the feasibility study of the direct detection technology of superparamagnetic nanoparticles: build a magnetic detection device based on magnetic induction coils, study the influence of different measurement conditions and detection methods on the quantitative measurement of magnetic particles, and initially realize the detection of mg-level magnetic particles.
(1) After setting up a uniform magnetic field, replace the previous single-coil detection with double-coil detection, and detect the induced voltage change of magnetic particles through the difference of the induced voltage in the two detection coils, which can reduce the influence of background noise on detection sensitivity .
Self-made detection coil pair
(2) Detection process: the signal generator outputs a voltage with a certain frequency and waveform, and the power amplifier amplifies the voltage output by the signal generator, so that the system replaces the separate drive coil with a uniform strength of the drive coil (the drive coil and the drive core) ) The drive capability is greatly increased, and another double-coil detection coil is used to conduct mutual inductance with this coil. The oscilloscope is used to directly detect the voltage difference between the two ends of the induction coil.
A magnetic sensor design scheme based on a uniform magnetic field and dual detection coils is constructed, and the existence of mg-level magnetic particles can be detected in this magnetic detection experimental device scheme. From the analysis of the results of this experiment, it can be seen that this method can also detect lower-quality magnetic particles. This experimental program verifies the feasibility of magnetic detection of superparamagnetic nanoparticles.
Parameters of the power amplifier ATA-4012 used in the experiment: